Given the official hints, I was actually thinking along the lines of whatsitcalled...
*looks it up*
Call of Juarez, the first one.
Although, I don't think it has anything to do with present time (obviously, being a wild west shooter - but are there any flashbacks? Err.. Flashforwards?), and I have no idea about the Ohio thing.
The other would be Assassin's Creed? Maybe?
They all seem to focus on karmic experiences, or redemption.
AC has more to do with the past and present overlapping.
Call of Juarez features two brothers who are very different, but compliment eachother. AC had that AI, or some such.
Call of Juarez has a messenger, of sorts? Wasn't one of the brothers a priest, and the other an outlaw? No idea about Assassin's Creed - never played it, don't know much about it.
And Ohio's secret place, well, I have no idea.
Just a thought. I know they're relatively new games, but it's a wild stab.
Has anyone mentioned Vampire: The Masquerade - Redemption? I would orgasm on the spot if that was released on GOG.