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I'm gonna echo the comment about a Noctura cooler and add in my own suggestion: a NZXT tower with enough drive bays that you won't be complaining. Optional but I'd suggest looking for is a UHD-friendly drive (or a BDXL drive). For the power, 850 might be enough but get platinium or better rated. Personally, if I had the cash, I'd go with a EVGA GTX 2080 ti FTW GAMING edition card but I may be biased on that. On the OS side, I'd actually go with a win 7 x64 parition and a win 10 pro x64 partition. Also, probably a couple extra HDD's for that 10 TB. Also, can't go wrong with getting aftermarket fans for the case as they'll work better.
What is the likelihood, over time, that regression bugs will diminish any any benefit from using a separate (Win7) gaming partition?

If the hassle isn't too much, I'd opt for a Linux distro with a Windoze partition, to complement anything not happy with WINE.

Then again, two OS kernels to maintain (who knows what M$ will bork in the future?) may be more than one wishes to take on.

What do Linux distro do readers recommend for best gaming?
You already got a few good advices in this thread, but if you're not in a need to get the system right now, my advice is to do a bit more research, look for reviews on specific products and things like that.

For power supply, Seasonic Prime Ultra 850 Platinum is probably the best choice. Or something similar from Super Flower. EVGA are good too because some of them are actually made by Super Flower and Seasonic. I would skip other brands. Here is a power supply calculator that will give you an idea how much your system will draw.

Unless you want to do some hardcore overclocking, I agree with others that the motherboard is overkill. Maybe pick something else from this list.

Noctua coolers are very good, but personally I'd go with be quiet! Dark Rock Pro 4. If you're not overclocking (and I see no poit in doing it on such system, unless you want more heat, noise and power consumption), a high end air cooler (Noctua or be quiet!) is a better choice than a liquid cooler. Some of those water pumps are actually noisier than the silent air coolers mentioned above.

The video card is nice, but why PNY? I'd go for something from EVGA, Asus, MSI or Gigabyte. They have different models for the same GPU, some at stock speeds, some overclocked - so look for reviews first.

A 2TB NVMe drive sounds nice, but a 500GB NVMe (for system, applications and maybe a few AAA games) and a 2TB SATA SSD (for games) would be cheaper, and you won't see more than 1-2 seconds difference in loading times for your games, between the NVMe and the SATA drive.

10TB hard drive is a big risk, unless you backup your data very often.

There are many things you can add to your system, a good gaming mouse, mechanical keyboard, some silent fans from be quiet!, maybe a fan controller for them, an external sound card, high quality speakers, a mouse bungee.

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idbeholdME: And you should also definitely get a monitor that is capable of utilizing all that power. So 2K @165Hz at least or go all out and get a 4K @165 Hz. G-sync is also pretty much a must have.
There are no 4K monitors above 144Hz, as far as a I know. There's a few of them at 144Hz, but they are around $2000. And the current generations of video cards can't do 4K at high refresh rates for recent AAA games on high details. Personally, I think the sweet spot for gaming monitors now is 27 inch 1440p @144Hz, preferably with IPS/PLS panel or at least VA panel. I had bad experiences with TN panels, so I stay away from them.
Post edited November 27, 2018 by ariaspi
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idbeholdME: And you should also definitely get a monitor that is capable of utilizing all that power. So 2K @165Hz at least or go all out and get a 4K @165 Hz. G-sync is also pretty much a must have.
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ariaspi: There are no 4K monitors above 144Hz, as far as a I know. There's a few of them at 144Hz, but they are around $2000. And the current generations of video cards can't do 4K at high refresh rates for recent AAA games on high details. Personally, I think the sweet spot for gaming monitors now is 27 inch 1440p @144Hz, preferably with IPS/PLS panel or at least VA panel. I had bad experiences with TN panels, so I stay away from them.
True. I meant those recent 144 Hz 4K monitors.

I personally find the sweet spot to be 24 inch 1440p @165Hz.