Artificiary: I was unable to launch the game when I first installed but found a solution on another forum (GameFaqs I believe). If this has already been covered I apologize, I did not read the entire thread. :)
I'm running a 30 inch monitor at 2560x1600. The game would not start at any resolution unless I chose the option to run in windowed mode. However, once I dropped my desktop resolution to 1680x1050 I was able to launch the game at 2560x1600 / full screen.
I have also read that there may be an issue with having multiple monitors connected. One user over at Hardforums said he couldn't launch the game until he disconnected his 2nd/3rd monitors.
Hope that helps someone!
I can launch the game with this solution, but when I choose "new game" and then a difficult "normal" the game just dies, and goes back to the launcher. I have tried every kind of resultion and windows mode, it doesn't matter :( .