I game I gave up maybe forever is
Legend of Grimrock. I don't think it's too hard, but I had thrown away a necessary item and couln't progress withouth it. I think that a game becoming unwinnable without even telling the player is unacceptable game design and won't play again. I have spent hours trying to figure out why I was stuck and that totally spoiled the fun. It's a pity, because I was enjoying it.
tinyE: I just remembered, I was never able to beat Macho Man on the original NES Mike Tyson's Punch Out.
Evidently I'm not the only one. In the game's prime there were A LOT of people who thought Tyson was easier to beat that Macho Man, and I knew a lot of people who had beaten Tyson but not Macho Man.
I recently finished
Snake Rattle 'n Roll with the aid of an emulator and instant save. Many games of the era were so difficult that it killed the fun and it seems like they were noot even made to the player to enjoy them or seem the end.
The Immortal is another title that comes to mind.
Some adventure games are enfuriating and can be solved olny following a solution.
The Feeble Files towards the end is one of those and I rage quit it.
A more recent title I gave up to near the end is
Limbo. I watched the ending on Youtube and was glad I hadn't wasted hours trying to reach the end as it was totally not worth it.