I'm left hander. I play with mouse in left hand and right hand on keyboard. Using WSAD is hard, so in every game i rebind it.
In Witcher 3 i can in options rebind keys. But when i bind apostrophe as move left button, it does not work in game.
It is configured in options, but game does not react when i push it.
I've checked config file (input.settings) and it looks OK, at least at first look - there is "IK_SingleQuote" binded to proper actions. But game does not react.
Any idea what to do?

if you bind to numpad kays it's the same? Did you tried?

On numpad keybinding works fine.
It's just inconvenient for me.
In every game i use same keyboard settings, only in Witcher 3 i can't. It's not even problem in CP2077, just Witcher 3.