Cattie: i would try to uninstall the game, delete the complete game-folder (not your saves, this folder is at another place). than reinstall it. some mods (like the console-mod) are installed in the game-folder, not the mod-folder. its hard to uninstall it.
I don't think it was related to mods...
I uninstalled, and noticed I had no leftover files, so there really were no mods... Then reinstalled from my old install files. and it refused to patch itself, so I uninstalled again, then re-downloaded ALL files (35+ GB), then installed them, Visual C++ redist refused to install properly, had to kill the task a few times (nice), then installed everything else in order, went to Galaxy... Didn't even have the game in it. So I imported my folder, and it wanted to download an extra GB of data... Okay, I hit Cancel, left everything, launched Witcher 3 from its start menu shortcut, which magically added the game back to Galaxy, without any need to download extra stuff (even after a 'Repair' step I initiated.) Kudos to the Galaxy/web/installer developers for doing things in such a complicated way.
Anyway, after several hours of work, it's now working again.
Also, it fixed the Price of Honor quest (unlockable chest), which I believe wasn't documented in the changelog... Or maybe it was fixed long ago but I needed to reinstall to get the fix to work, I don't know. I don't want to know. My copy is ready for Blood & Wine and it's free of any quests, that's all I needed.