For some reason a portion of the screen does not allow me to click on it in the game. Whether it's the main menu or in game, the area highlighted on the attached screenshot does not do anything if I click or otherwise have my mouse on it (will not highlight menu items, game objects, nothing).

Using the default 800x600 60hz it blocks a good portion of the screen and is very obnoxious to try to play around...

I've tried playing around with the nwconfig.exe to change the resolution, but all it does is make the game smaller while still having that unclickable area, just located farther off to the side of the playable portion of the screen (see the 1280x800 screenshot).

I also tried changing the Compatibility settings and "Disable full screen optimazations", "Run in 640 x 480 screen resolution", and "Override high DPI scaling behavior" with no difference whatsoever.

I read some other people had some different issues while trying to play fullscreen, so I figured would try running it Windowed , but I can't get that to work (tried alt+enter, also tried editing the nwn.ini file to change it to "FullScreen=0", but I just can't get it windowed.

Can anyone help?

I've...never heard of this before in over 15 years. You don't have this problem with any other game?

Nope, I've never seen this before either.

Try a critical rebuild for kicks?