Yesterday I was playing the game, when all of a sudden the game just locked up.
Actually it cause my entire computer to lock up, I had to do a hard reboot to get it running again, I could not even open the task manager.

Today when I tried launching the game I again I get the standard windows error NWN2 stopped working with the standard options to look for solutions on the Internet and close the program or just close the program.

I figured that uninstalling and reinstalling the game would solve it, but it did not.
I even ran a file integrity check during installation, it made no difference
I simply cannot launch the game, every time I try to start the game I instantly get the error.

I'm running Win 7 with the latest updates/drivers installed, played the game on Win 7 before and never had this problem.

Problem details as listed in the crash report in case it makes sense for someone(had to use google translate),

Problem signature:
Problem Event Name: APPCRASH   
Program Name: nwn2main.exe
Application Version: 1.0.23.1765
Timestamp for the program: 4a89f7b8
Name of error module: StackHash_0a9e
Fault Module Version: 0.0.0.0
Timestamp error module: 00000000
Exception Code: c0000005
Exception Offset: 00000000
OS Version: 6.1.7601.2.1.0.768.3
ID for national(Local regional?) settings: 1044
Additional Information 1: 0a9e
Additional Information 2: 0a9e372d3b4ad19135b953a78882e789
Additional Information 3: 0a9e
Additional Information 4: 0a9e372d3b4ad19135b953a78882e789

That's a rather generic error and could be caused by almost everything. Have you tried starting the game as Administrator (right-click => Run as ..) yet, or in Compatibility Mode for Win XP (right-click => Properties => Compatibility tab)?

Further, don't install the game into "Program Files" folder but into a custom location like C:\GOG Games\

There's also the NWN2 Client Extension a kind of community patch to fix and improve mainly multiplayer features, but it comes with its own launcher and fixes some crash bugs as well. Maybe worth a try here.

In the properties box for the shortcut, the box that says "run as admin" was marked so it should have run as admin automatically.
I tried to right click and the selected run as admin and that worked, but left clicking still didnt work.
Then I set it to run in compatibility mode for XP SP3, that seems to have solved the problem.

I should have thought of this myself.
Thanks for the help.