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Lots of people here don't like the way they changed quickhacks and the netrunner experience when moving from 1.63 to v2.0 and beyond. I get it, it's jarring.

People have posted this stuff on the Steam forums, but I don't remember seeing it here so here goes:

If you want "pure" quickhack domination of most if not all mooks (including the skull elites, I think?), all you need is:

15+ Intelligence
Tier 3 or higher Sonic Shock (no traceback)
Tier 5 Synapse Burnout (Iconic or not, doesn't really matter)
Access to Overclock
Access to quickhack queues

What other perks/synergies you use is up to you, I'm just laying out the basics.

From stealth, dump Sonic Shock and then Synapse Burnout into the queue on your first victim, in that order. Keep doing this to more targets until you run out of RAM. Then activate Overclock, and start burning up your HP. Every time you incapacitate an enemy (yes, Synapse Burnout isn't necessarily lethal anymore, for some reason), you'll get 5 more seconds on Overclock, allowing it to last infinitely until you run out of enemies. As long as you keep using Sonic Shock, almost nobody can trace you (rare exceptions). It helps to have a lot in Body and Tech for extra HP, supporting cyberware that will either increase your RAM regen rate or give you RAM back for taking out an enemy (and Heal on Kill helps here too!), maybe even stuff like Blood Pump, etc. Though in my limited experience, just using a few of the healing item perks from the Tech tree along with Tier 5 Bounce Back and Adrenaline perks from the Body tree lets me go through a lot of enemies, and my character isn't even a dedicated netrunner. You can do better.

With enough planning, there's really nothing stopping you from dumping an endless stream of Synapse Burnouts onto bosses too, I just haven't worked out all the details, but seriously, that's all there is to it.

Unless you really want to branch out into monowhips or smart weapons, you just don't need them, nor do you necessarily need to get close to your victims or do the occasional takedown to reset traces.